Complex Genomic Rearrangements (CGRs) are an important aspect of the genomic landscape of many tumours. CGRs often disrupt genes and fuse other genes, in some cases promoting tumour development. nFuse predicts fusion transcripts and associated CGRs from matched RNA-seq and Whole Genome Shotgun Sequencing (WGSS).
nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing
Genome Res. 2012. 22: 2250-2261
Presented at RECOMBÕ12 (16th Annual International Conference on Research in Computational Molecular Biology), Barcelona, Spain, April 21-24 2012
Journal link | PubMed ID: 22745232